Thursday 22 October 2015

Why Complementary Medicine is better than Ibuprofen or Paracetamol in the prevention, and treatment of respiratory infections (common cold and Flu)

Why Complementary Medicine is better than Ibuprofen or Paracetamol in the prevention, and treatment of respiratory infections (common cold and Flu)



Most people at one time or another will catch a common cold or flu. Many different types of viruses cause these infections and it is these viruses that infect the nose, throat and upper respiratory tract causing pain, congestion and fever.
Common sense tells us that keeping warm and avoiding sudden temperature changes, such as, leaving a warm home or office for the cold outdoors will reduce the chances of catching a cold or flu. Always don warm clothing when moving from a warm to a cold environment as these sudden changes in temperature lower resistance to infection without adequate protection.
Unfortunately many people just continue doing work and play without rest and use analgesics and other cold formula to just “push on through”. Although these may ease the aches and pains associated with respiratory infections they don’t reduce your spreading the cold to others and in fact may worsen the symptoms and increase time needed till recovery. Although in some cases we just may need something to get through an important event taking analgesics may help, but prevention and a reduction of the duration and symptoms of a respiratory infection is the best way and complementary medicine may just have the answer.
There are many herbs, vitamins and minerals that have a positive effect in reducing the incidence, duration and symptoms of respiratory infection and following is factual information on the most commonly used.

The evidence
Paracetamol and Ibuprofen
Paracetamol and or Ibuprofen could prolong the symptoms of respiratory infections
A study found patients were more likely to come back within a month with worsening symptoms or new symptoms if they were prescribed ibuprofen or ibuprofen with paracetamol for the symptoms of the common cold. Between 50 per cent and 70 per cent of participants in this study who were prescribed ibuprofen or ibuprofen with paracetamol had elongation and worsening of the symptoms that required returning to their doctor.(1)

Vitamin D3
Low vitamin D status is associated with higher rate of respiratory infections
A large study of 18,883 people reported strong association between low blood levels of vitamin D (25OHVitD)and increased respiratory infections. Those with the lowest blood vitamin D levels reported having significantly more recent colds or flu and the risks were even higher for those with chronic respiratory disorders, including asthma and COPD. Those with low vitamin D levels were
nearly 40 per cent more likely to have had a respiratory infection than those with adequate vitamin D levels (2).
Other findings support the concept of vitamin D possessing important pleiotropic actions outside of calcium homeostasis and bone metabolism. In children, an association of nutritional rickets with respiratory compromise has long been recognized. Epidemiologic studies clearly demonstrate the link between vitamin D deficiency and the increased incidence of respiratory infections (3)

Vitamin D3 supplements found to reduce the incidence of influenza in School children
A recent randomised double-blind, placebo-controlled trial among School Children in Japan was conducted. The Children were randomly divided into two groups: One group received daily supplements of 1200iu daily of vitamin D3, while the other group received a placebo. The children were then assessed for the incidence of influenza over the 2008 to 2009 winter period.
The study found that the incidence of influenza was 10.8 per cent in the vitamin D3 supplemented group, compared with 18.6 per cent in the placebo group; this reduction was even greater for those who had low vitamin D (25OHVitD), with a 74 per cent reduction in the incidence of influenza.
Also, asthma attacks were significantly reduced in asthmatic children in the vitamin D3 supplemented group(4)

Vitamin C
Vitamin C reduces the symptoms and duration of respiratory infections (common cold)
Correct nutrition is also a necessity, we should always endeavour to include plenty of fresh fruit and vegetables in the daily diet as these are a good source of vitamin C.
Studies and clinical trials have shown that supplementing with vitamin C and vitamin E can help strengthen the immune system reducing the incidence and symptoms of colds and flu (5)
Vitamin C supplementation can start with bottle fed babies. Blackcurrant and rose hip formulas high in vitamin C are readily available. These fruit juice formulas should be included in baby’s daily feeding routine. Children over two years of age can either have a crushed Children's Chewable Vitamin C tablet added to their food or chew one tablet twice daily and adults should take between 1,000 mg and 2,000mg daily. In six trials with participants exposed to short periods of extreme physical or cold stress or both (including marathon runners and skiers) vitamin C reduced the common cold risk by half. (6)
In thirty-one comparisons studies that examined the effect of regular vitamin C  supplementation on common cold duration (9745 episodes). In adults the duration of colds was reduced by 8% (3% to 12%) and in children by 14% (7% to 21%). In children, 1 to 2 g/day vitamin C shortened colds by 18%. The severity of colds was also reduced by regular vitamin C administration(7)

Echinacea
Echinacea found to reduce the incidence   and the duration of respiratory infections
Echinacea is one of the most commonly used herbal products, but controversy exists about its benefit in the prevention and treatment of the common cold. A  meta-analysis evaluating the effect of echinacea on the incidence and duration of the common cold was undertaken. The meta-analysis included   14 studies were where Incidence of the common cold was reported
The results found that Echinacea decreased the odds of developing the common cold by 58% and the duration of a cold by 1·4 days . The authors concluded that published evidence supports echinacea's benefit in decreasing the incidence and duration of the common cold.(8)

Lactoferrin
Lactoferrin found to reduce the incidence of the common cold
Lactoferrin is a compound that is naturally produced in the body by immune cells and it is particularly prevalent in secretions of the upper airways, eyes and stomach.  Bovine lactoferrin supplementation has been shown to boost the activity of certain immune cells. One study found that the total number of cold-associated symptoms reported by participants that received a Lactoferrin/whey compound (Lf/IgF) was significantly less than those in the placebo group. Also, total days sick with a cold and cold severity were reduced over the clinical trial period for Lf/IgF over placebo, but the trend was not significant(9)

Health Department Warning
Call the Poisons Information Centre on 13 11 26 (Australia) if a child, young person or adult has taken more paracetamol or ibuprofen than is recommended. 
Paracetamol in large doses can cause severe liver damage Also thousands of people attend Hospital Emergency Rooms in Australia each year with suspected or known overdose.

Use in the elderly
Ibuprofen should not be taken by adults over the age of 65 without careful consideration of co-morbidities and co-medications because of an increased risk of adverse effects, in particular heart failure, gastro-intestinal ulceration and renal impairment.

Use in pregnancy
Category C: Ibuprofen inhibits prostaglandin synthesis and, when given during the latter part of pregnancy, may cause closure of the foetal ductus arteriosus, foetal renal impairment, inhibition of platelet aggregation and may delay labour and birth. Use of ibuprofen is thus contraindicated during the third trimester of pregnancy, including the last few days before expected birth
The information given by Naturopath Russell Setright in this article is for general educational purposes only and not for the treatment of any disease or condition. Always see your Healthcare Practitioner for any suspected disease accident or condition and follow there expert advice.


References;
1.              P. Little, M. Moore, et al. Ibuprofen, paracetamol, and steam for patients with respiratory tract infections in primary care: pragmatic randomised factorial trial. BMJ, 2013; 347 (oct25 2)
2.                   Adit A. Ginde, MD, MPH; Jonathan M. et al.  Association Between Serum 25-Hydroxyvitamin D Level and Upper Respiratory Tract Infection in the Third National Health and Nutrition Examination Survey. Arch.  Intern.  Med. 2009;169(4):384-390
3.                Walker VP, Modlin RL.  The vitamin D connection to pediatric infections and immune function. Pediatr Res. 2009 May;65(5 Pt 2):106R-113R.
4.               Urashima U, et al. “Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren” American Journal of Clinical Nutrition, March 10, 2010.
5.              Hemila, H. “Vitamin C and the Common Cold” Br. J. Nutrition” 67(1);316, January, 1992
6.              Hemilä H, et al. Vitamin C for preventing and treating the common cold. Cochrane Database of Systematic Reviews 2007
7.              Harri Hemilä1, et al. Vitamin C for preventing and treating the common cold Editorial Group: Cochrane Acute Respiratory Infections Group, Published Online: 31 JAN 2013
8.              Sachin A Shah PharmD a c, Stephen Sander PharmD et al. Evaluation of echinacea for the prevention and treatment of the common cold: a meta-analysis The Lancet Infectious Diseases, Volume 7, Issue 7, Pages 473 - 480, July 2007
9.         Luis Vitettaemail, Samantha Coulson et al, The clinical efficacy of a bovine lactoferrin/whey protein Ig-rich fraction (Lf/IgF) for the common cold: A double blind randomized study, Complementary Therapies in Medicine Volume 21, Issue 3 , Pages 164-171, June 2013

Tuesday 20 October 2015

Russell's latest amino acids boost performance and muscles in athletes

Branch-chain amino acids can reduce muscle loss and improve athletic performance 


 Branched-chain amino acid leucine, isoleucine and valine supplements are extremely popular and have been found to boost protein synthesis during and after heavy exercise and may also help improve physical performance. A study reported in Amino Acids 1993;4:255-266 found that athletes supplementing with these BCAA demonstrated a significant improvement in exercise performance. Another study found that BCAA supplementation can reduce muscle breakdown in athletes (Effect of Branch-Chain Amino Acids Supplementation on the Exercise-Induced Change in Aromatic Amino Acid Concentration in Human Muscle, Blomstrand, E et al, ACTA Physiol Scand, 1992;146:293-298)

Older athletes can also benefit from BCAA supplementation. Studies have found that in older adults supplemented with 4g of leucine per meal improved muscle protein synthesis(Casperson SL et al.: L-Leucine supplementation chronically improves muscle protein synthesis in older adults consuming the RDA for Protein; Clin Nutr. 2012 Feb 20)

In a study that used supplements of Beta-hydroxy-beta-methylbutyrate (HMB) a metabolite of leucine, a branched-chain amino acid found those athletes taking a whey supplement with a HBA and isomaltulose a slow release carbohydrate, had a reduced muscle damage and improved athletic performance.

The authors of this study suggested that whey protein supplementation can be optimized for muscle recovery during intense conditioning by adding HMB and a slow-release carbohydrate.
(William J. Kraemer, David R. Hooper, et al. The Addition of Beta-hydroxy-beta-methylbutyrate and Isomaltulose to Whey Protein Improves Recovery from Highly Demanding Resistance Exercise. Journal of the American College of Nutrition, 2015; 34 (2): 91)

Good food sources of BCAA
Foods high in L-Leucine
Beef approx.                      1690mg /100g,
Salmon approx.                 1615mg /100g,
Eggs approx.                      1090mg/100g (2 medium eggs)
Wheat products approx.   920mg/100g.

Foods high in L-Valine and L-Isoleucine
Meat and other animal produce.
Dried peas approx.           1160mg/100 g
Walnuts approx.                750mg/100g   are particularly suited for vegetarians with their high    BCAA concentration.

MEAL SUPPLEMENTS

Michelle Bridges Chocolate or Vanilla Protein Blend with Ancient Grains.
The unique brown rice and pea protein blend found in Michelle Bridges Chocolate Protein Blend with Ancient Grains is packed with key amino acids for muscle growth including the branched-chain amino acids leucine, isoleucine and valine and essential amino acids lysine and arginine
25gr 1n 250ml of skim milk or water twice daily
BCAA content in 25g in water.
Vanilla                                Chocolate
Leucine       1562 mg            1612 mg
Isoleucine    889 mg             927 mg

Valine          1019 mg            1031 mg

Wednesday 14 October 2015

Potassium-magnesium citrate supplements is an effective prophylaxis against recurrent calcium oxalate kidney stones

Potassium-magnesium citrate is an effective prophylaxis against recurrent calcium oxalate nephrolithiasis.

Potassium-magnesium citrate is an effective prophylaxis against recurrent calcium oxalate nephrolithiasis.
Ettinger B1, Pak CY, Citron JT, Thomas C, Adams-Huet B, Vangessel A.
Abstract
PURPOSE:
We examined the efficacy of potassium-magnesium citrate in preventing recurrent calcium oxalate kidney calculi.
MATERIALS AND METHODS:
We conducted a prospective double-blind study of 64 patients who were randomly assigned to receive placebo or potassium-magnesium citrate (42 mEq. potassium, 21 mEq. magnesium, and 63 mEq. citrate) daily for up to 3 years. RESULTS. New calculi formed in 63.6% of subjects receiving placebo and in 12.9% of subjects receiving potassium-magnesium citrate. When compared with placebo, the relative risk of treatment failure for potassium-magnesium citrate was 0.16 (95% confidence interval 0.05 to 0.46). Potassium-magnesium citrate had a statistically significant effect (relative risk 0.10, 95% confidence interval 0.03 to 0.36) even after adjustment for possible confounders, including age, pretreatment calculous event rate and urinary biochemical abnormalities.
CONCLUSIONS:

Potassium-magnesium citrate effectively prevents recurrent calcium oxalate stones, and this treatment given for up to 3 years reduces risk of recurrence by 85%.

J Urol. 1997 Dec;158(6):2069-73.

Study found Calcium Supplements reduced diastolic blood pressure

The effect of supplementary calcium on blood pressure in healthy adult women aged 18-30 years in Tehran, Iran.

Abstract
INTRODUCTION:
Cardiovascular disease is the major cause of mortality in developed countries and has an increasing trend in developing countries. There are some evidences that calcium supplementation may decrease blood pressure and consequently cardiovascular disease, but they are not conclusive and there is no agreement in this respect. The aim of the present study was to assess the effect of supplementary calcium on systolic and diastolic blood pressure in healthy adult women aged 18-30 years.

MATERIALS AND METHODS:
Seventy-five normotensive volunteers were randomly divided into two groups, the treatment group received 1000 mg/day calcium (four doses of 625 mg calcium carbonate) for 1 month and the control group received placebo (dextrose). Systolic and diastolic blood pressure was determined before and after intervention in supine position after 10 min of rest.

RESULTS:
The mean daily calcium intake from food was 773.9 mg in treatment and 721 mg in control group (no significant difference) but in both the groups dietary calcium intake was less than the recommended dietary allowance: After calcium supplementation, the mean change of systolic blood pressure was not significant in the two groups, but diastolic blood pressure reduced in treatment group and increased in control group (-4.9 vs 2.6 mmHg) (P < 0.05).

CONCLUSIONS:
These results suggest that, calcium supplementation does not have any effect on systolic blood pressure of our volunteers but can decrease diastolic blood pressure significantly and therefore it seems that calcium supplementation may be useful for people with increased diastolic blood pressure, especially for those who receive less calcium than recommended dietary allowance.


J Educ Health Promot. 2015 Aug 6;4:67. doi: 10.4103/2277-9531.162388. eCollection 2015.

Higher calcium intake from non-dairy and dairy sources reduces risk of kidney stones

Dietary Calcium from Dairy and Non-dairy Sources, and Risk of Symptomatic Kidney Stones
Purpose
Because of high correlations between dairy intake and total dietary calcium, previously reported associations between lower calcium intake and increased kidney stone risk represent de facto associations between milk products and risk. We examined associations between dietary calcium from nondairy and dairy sources, and symptomatic nephrolithiasis.

Materials and Methods
We performed prospective studies in the Health Professionals Follow-up Study (HPFS) in 30,762 men, and in the Nurses' Health Study (NHS) I and II in 94,164 and 101,701 women, respectively. We excluded men 60 years old or older because we previously reported inverse associations between calcium intake and risk only in men younger than 60 years. Food frequency questionnaires were used to assess calcium intake every 4 years. We used Cox proportional hazards regression to adjust for age, body mass index, supplemental calcium, diet and other factors.

Results
We documented 5,270 incident kidney stones during the combined 56 years of followup. In participants in the highest vs the lowest quintile of nondairy dietary calcium the multivariate relative risk of kidney stones was 0.71 (95% CI 0.56–0.92, p for trend 0.007) in HPFS, 0.82 (95% CI 0.69–0.98, p trend 0.08) in NHS I and 0.74 (95% CI 0.63–0.87, p trend 0.002) in NHS II. When comparing the highest to the lowest quintile of dairy calcium, the multivariate relative risk was 0.77 (95% CI 0.63–0.95, p trend 0.01) for HPFS, 0.83 (95% CI 0.69–0.99, p trend 0.05) for NHS I and 0.76 (95% CI 0.65–0.88, p trend 0.001) for NHS II.

Conclusions
Higher dietary calcium from nondairy or dairy sources is independently associated with a lower kidney stone risk.

Russel's Note Vitamin D supplementation also decreased urinary calcium excretion as well as stone growth, suggesting that it may help prevent the risk of stone formation.
Dietary Calcium from Dairy and Non-dairy Sources, and Risk of Symptomatic Kidney Stones The Journal of Urology, October 2013Volume 190, Issue 4, Pages 1255–1259

Sunday 4 October 2015

vitamin C halves the incidence of the common cold in runners

Vitamin C is beneficial against the common cold


According to an updated Cochrane review on vitamin C and the common cold, vitamin C seems to be particularly beneficial for people under heavy physical stress. In five randomized trials of participants with heavy short-term physical stress, vitamin C halved the incidence of the common cold. Three of the trials studied marathon runners, one studied Swiss school children in a skiing camp and one studied Canadian soldiers during a winter exercise.

Furthermore, in a recent randomized trial carried out with adolescent competitive swimmers, vitamin C halved the duration of colds in males, although the vitamin had no effect on females.
Regular doses of vitamin C of one gram per day or higher have reduced the average duration of colds in adults by 8% and in children by 18%. Although these findings unambiguously show that vitamin C has a biological effect on colds, taking vitamin C every day to shorten infrequent colds does not seem reasonable. On average, adults have only a few common cold episodes per year and children have some half a dozen colds per year.

Few therapeutic trials, meaning trials in which vitamin C was given only after the first symptoms of a cold appeared, have been carried out and their results are not consistent. Nevertheless, given the consistent effect of vitamin C on the duration and severity of colds in the regular supplementation studies, and the safety and low cost of vitamin C, the authors consider that it may be worthwhile for individual common cold patients to test whether therapeutic vitamin C is beneficial for them.

Vitamin C for preventing and treating the common cold
Harri Hemilä1,*, Elizabeth Chalker2Editorial Group: Cochrane Acute Respiratory Infections Group